The Neuroblastoma Foundation

Ceruloplasmin deficiency reduces levels of iron and BDNF in the cortex and striatum of young mice and increases their vulnerability to stroke.

pubmed: neuroblastoma — Sat, 04 Feb 2012 11:46:08 GMT

Ceruloplasmin deficiency reduces levels of iron and BDNF in the cortex and striatum of young mice and increases their vulnerability to stroke. PLoS One. 2011;6(9):e25077 Authors: Texel SJ, Zhang J, Camandola S, Unger EL, Taub DD, Koehler RC, Harris ZL, Mattson MP Abstract Ceruloplasmin (Cp) is an essential ferroxidase that plays important roles in cellular iron trafficking. Previous findings suggest that the proper regulation and subcellular localization of iron are very important in brain cell function...(read more)

Acitretin, an Enhancer of Alpha-Secretase Expression, Crosses the Blood-Brain Barrier and Is Not Eliminated by P-Glycoprotein.

pubmed: neuroblastoma — Sat, 04 Feb 2012 11:46:08 GMT

Acitretin, an Enhancer of Alpha-Secretase Expression, Crosses the Blood-Brain Barrier and Is Not Eliminated by P-Glycoprotein. Neurodegener Dis. 2012 Feb 1; Authors: Holthoewer D, Endres K, Schuck F, Hiemke C, Schmitt U, Fahrenholz F Abstract Background: ADAM10 (a disintegrin and metalloproteinase 10) has been demonstrated to act as the main physiological α-secretase. Enzymatic activity of the α-secretase on the one hand prevents the formation of toxic Aβ peptides and on the other hand promotes the...(read more)

The dopamine metabolite aminochrome inhibits mitochondrial complex I and modifies the expression of iron transporters DMT1 and FPN1.

pubmed: neuroblastoma — Sat, 04 Feb 2012 11:46:07 GMT

The dopamine metabolite aminochrome inhibits mitochondrial complex I and modifies the expression of iron transporters DMT1 and FPN1. Biometals. 2012 Feb 3; Authors: Aguirre P, Urrutia P, Tapia V, Villa M, Paris I, Segura-Aguilar J, Núñez MT Abstract Hallmarks of idiopathic and some forms of familial Parkinson's disease are mitochondrial dysfunction, iron accumulation and oxidative stress in dopaminergic neurons of the substantia nigra. There seems to be a causal link between these three conditions...(read more)

Novel GαS-Protein Signaling Associated with Membrane-Tethered Amyloid Precursor Protein Intracellular Domain.

pubmed: neuroblastoma — Sat, 04 Feb 2012 11:45:40 GMT

Novel GαS-Protein Signaling Associated with Membrane-Tethered Amyloid Precursor Protein Intracellular Domain. J Neurosci. 2012 Feb 1;32(5):1714-29 Authors: Deyts C, Vetrivel KS, Das S, Shepherd YM, Dupré DJ, Thinakaran G, Parent AT Abstract Numerous physiological functions, including a role as a cell surface receptor, have been ascribed to Alzheimer's disease-associated amyloid precursor protein (APP). However, detailed analysis of intracellular signaling mediated by APP in neurons has been lacking...(read more)

An extension of the single threshold design for monitoring efficacy and safety in phase II clinical trials.

pubmed: neuroblastoma — Fri, 03 Feb 2012 11:06:05 GMT

An extension of the single threshold design for monitoring efficacy and safety in phase II clinical trials. Stat Med. 2011 Jun 30;30(14):1648-64 Authors: Brutti P, Gubbiotti S, Sambucini V Abstract Tan and Machin (biStat. Med. 2002; 21:1991-2012) introduce a Bayesian two-stage design for phase II clinical trials where the binary endpoint of interest is treatment efficacy. In this paper we propose an extension of their design to incorporate safety considerations. At each stage we define the treatment...(read more)

Childhood cancer incidence and survival 2003-2005, Thailand: study from the thai pediatric oncology group.

pubmed: neuroblastoma — Fri, 03 Feb 2012 11:06:05 GMT

Childhood cancer incidence and survival 2003-2005, Thailand: study from the thai pediatric oncology group. Asian Pac J Cancer Prev. 2011;12(9):2215-20 Authors: Wiangnon S, Veerakul G, Nuchprayoon I, Seksarn P, Hongeng S, Krutvecho T, Sripaiboonkij N Abstract Background: Previous population-based incidences of childhood cancer in Thailand were achieved by extrapolating from data limited to a small number of cancer registries, not from the whole country. In addition, survival of childhood cancer patients...(read more)

Cellular consequences of the expression of Alzheimer's disease-causing presenilin 1 mutations in human neuroblastoma (SH-SY5Y) cells.

pubmed: neuroblastoma — Fri, 03 Feb 2012 11:06:05 GMT

Cellular consequences of the expression of Alzheimer's disease-causing presenilin 1 mutations in human neuroblastoma (SH-SY5Y) cells. Brain Res. 2012 Jan 12; Authors: Boyle JP, Hettiarachchi NT, Wilkinson JA, Pearson HA, Scragg JL, Lendon C, Al-Owais MM, Kim CB, Myers DM, Warburton P, Peers C Abstract Mutations in the presenilin 1 (PS1) gene lead to early-onset Alzheimer's disease with the S170F mutation causing the earliest reported age of onset. Expression of this, and other PS1 mutations...(read more)

Protection of prenylated flavonoids from mori cortex radicis (Moraceae) against nitric oxide-induced cell death in neuroblastoma SH-SY5Y cells.

pubmed: neuroblastoma — Fri, 03 Feb 2012 11:06:04 GMT

Protection of prenylated flavonoids from mori cortex radicis (Moraceae) against nitric oxide-induced cell death in neuroblastoma SH-SY5Y cells. Arch Pharm Res. 2012 Jan;35(1):163-70 Authors: Lee HJ, Lyu da H, Koo U, Nam KW, Hong SS, Kim KO, Kim KH, Lee D, Mar W Abstract Seven prenylated flavanoids, licoflavone C (1), cyclomulberrin (2), neocyclomorusin (3), sanggenon I (4), morusin (5), kuwanon U (6) and kuwanon E (7), and three 2-arylbenzofurans, moracin P (8), moracin O (9), and mulberrofuran Q...(read more)

Arylpiperazine Dopamineric Ligands Protect Neuroblastoma Cells from Nitric Oxide (NO)-Induced Mitochondrial Damage and Apoptosis.

pubmed: neuroblastoma — Fri, 03 Feb 2012 11:06:04 GMT

Arylpiperazine Dopamineric Ligands Protect Neuroblastoma Cells from Nitric Oxide (NO)-Induced Mitochondrial Damage and Apoptosis. ChemMedChem. 2012 Feb 1; Authors: Tovilovic G, Zogovic N, Harhaji-Trajkovic L, Misirkic-Marjanovic M, Janjetovic K, Vucicevic L, Kostic-Rajacic S, Schrattenholz A, Isakovic A, Soskic V, Trajkovic V Abstract The protective ability of novel arylpiperazine-based dopaminergic ligands against nitric oxide (NO)-mediated neurotoxicity is investigated. The most potent neuroprotective...(read more)

Tumor-initiating cells in childhood neuroblastoma--letter.

pubmed: neuroblastoma — Fri, 03 Feb 2012 11:06:04 GMT

Tumor-initiating cells in childhood neuroblastoma--letter. Cancer Res. 2012 Feb 1;72(3):821-2 Authors: Mohlin S, Pietras A, Wigerup C, Ora I, Andäng M, Nilsson K, Olofsson T, Gisselsson D, Påhlman S PMID: 22298597 [PubMed - in process]...(read more)

Tumor-initiating cells in childhood neuroblastoma--response.

pubmed: neuroblastoma — Fri, 03 Feb 2012 11:06:04 GMT

Tumor-initiating cells in childhood neuroblastoma--response. Cancer Res. 2012 Feb 1;72(3):823-4 Authors: Hansford LM, Kaplan DR PMID: 22298598 [PubMed - in process]...(read more)

Activated β-catenin Forces N2A Cell-derived Neurons Back to Tumor-like Neuroblasts and Positively Correlates with a Risk for Human Neuroblastoma.

pubmed: neuroblastoma — Fri, 03 Feb 2012 11:05:52 GMT

Activated β-catenin Forces N2A Cell-derived Neurons Back to Tumor-like Neuroblasts and Positively Correlates with a Risk for Human Neuroblastoma. Int J Biol Sci. 2012;8(2):289-97 Authors: Zhi F, Gong G, Xu Y, Zhu Y, Hu D, Yang Y, Hu Y Abstract Neuroblastoma is an embryonic malignancy arising from neuroblasts. The mechanisms that regulate the origination of neuroblastoma are still not very clear. In this study, we revealed that 6-bromoindirubin 3'-oxime (BIO), a specific GSK-3β inhibitor, promoted...(read more)

Influence of a 50 Hz magnetic field and of all-trans‑retinol on the proliferation of human cancer cell lines.

pubmed: neuroblastoma — Thu, 02 Feb 2012 12:01:00 GMT

Influence of a 50 Hz magnetic field and of all-trans‑retinol on the proliferation of human cancer cell lines. Int J Oncol. 2012 Jan 27; Authors: Trillo MA, Martínez MA, Cid MA, Leal J, Ubeda A Abstract In vitro exposure to power frequency magnetic fields (MF) has been reported to influence cell proliferation and differentiation. However, the nature of the response of different human cancer cell types to these fields has not been sufficiently characterized. The present work investigates the response...(read more)

Shifting from Population-wide to Personalized Cancer Prognosis with Microarrays.

pubmed: neuroblastoma — Thu, 02 Feb 2012 12:00:59 GMT

Shifting from Population-wide to Personalized Cancer Prognosis with Microarrays. PLoS One. 2012;7(1):e29534 Authors: Shao L, Fan X, Cheng N, Wu L, Xiong H, Fang H, Ding D, Shi L, Cheng Y, Tong W Abstract The era of personalized medicine for cancer therapeutics has taken an important step forward in making accurate prognoses for individual patients with the adoption of high-throughput microarray technology. However, microarray technology in cancer diagnosis or prognosis has been primarily used for...(read more)

Calpastatin upregulation in Mycoplasma hyorhinis-infected cells is promoted by the mycoplasma lipoproteins via the NF-κB pathway.

pubmed: neuroblastoma — Wed, 01 Feb 2012 11:41:59 GMT

Calpastatin upregulation in Mycoplasma hyorhinis-infected cells is promoted by the mycoplasma lipoproteins via the NF-κB pathway. Cell Microbiol. 2012 Jan 31; Authors: Elkind E, Vaisid T, Kornspan JD, Barnoy S, Rottem S, Kosower NS Abstract Mycoplasma hyorhinis frequently contaminates cultured cells, with effects on synthetic and metabolic pathways. We demonstrated for the first time that contamination of cells by a strain of M. hyorhinis (NDMh) results in increased levels of calpastatin (the endogenous...(read more)

Rapid Detection of Neoplastic Cells in Serous Cavity Effusions in Children with Flow Cytometry Immunophenotyping.

pubmed: neuroblastoma — Wed, 01 Feb 2012 11:41:58 GMT

Rapid Detection of Neoplastic Cells in Serous Cavity Effusions in Children with Flow Cytometry Immunophenotyping. Leuk Lymphoma. 2012 Jan 30; Authors: Shen H, Tang Y, Xu X, Wang L, Wang Q, Xu W, Song H, Zhao Z, Wang J Abstract Abstract The aim of the study was to evaluate the role of flow cytometric immunophenotyping (FCI) as a quick diagnostic tool for pediatric malignancy in serous cavity effusions (SCE). FCI results on 103 SCE in a pediatric population were compared with retrospective clinical...(read more)

Suppression of p75 Neurotrophin Receptor Surface Expression with Intrabodies Influences Bcl-xL mRNA Expression and Neurite Outgrowth in PC12 Cells.

pubmed: neuroblastoma — Wed, 01 Feb 2012 11:41:47 GMT

Suppression of p75 Neurotrophin Receptor Surface Expression with Intrabodies Influences Bcl-xL mRNA Expression and Neurite Outgrowth in PC12 Cells. PLoS One. 2012;7(1):e30684 Authors: Zhang C, Helmsing S, Zagrebelsky M, Schirrmann T, Marschall AL, Schüngel M, Korte M, Hust M, Dübel S Abstract BACKGROUND: Although p75 neurotrophin receptor (p75NTR) is the first neurotrophin receptor isolated, its diverse physiological functions and signaling have remained elusive for many years. Loss-of-function phenotypic...(read more)

Liposome-encapsulated curcumin suppresses neuroblastoma growth through nuclear factor-kappa B inhibition.

pubmed: neuroblastoma — Tue, 31 Jan 2012 11:23:30 GMT

Liposome-encapsulated curcumin suppresses neuroblastoma growth through nuclear factor-kappa B inhibition. Surgery. 2012 Jan 26; Authors: Orr WS, Denbo JW, Saab KR, Myers AL, Ng CY, Zhou J, Morton CL, Pfeffer LM, Davidoff AM Abstract BACKGROUND: Nuclear factor-κB (NF-κB) has been implicated in tumor cell proliferation and survival and in tumor angiogenesis. We sought to evaluate the effects of curcumin, an inhibitor of NF-κB, on a xenograft model of disseminated neuroblastoma. METHODS: For in vitro...(read more)

Chemotherapy-Associated Angiogenesis in Neuroblastoma Tumors.

pubmed: neuroblastoma — Tue, 31 Jan 2012 11:23:30 GMT

Chemotherapy-Associated Angiogenesis in Neuroblastoma Tumors. Am J Pathol. 2012 Jan 26; Authors: Michaelis M, Hinsch N, Michaelis UR, Rothweiler F, Simon T, Wilhelm Doerr H, Cinatl J, Cinatl J Abstract The influences of cytotoxic drugs on endothelial cells remain incompletely understood. Herein, we examined the effects of chemotherapeutic agents in experimental angiogenesis models and analyzed vessel densities in clinical neuroblastoma tumor samples. Cisplatin (20 to 500 ng/mL), doxorubicin (4 to...(read more)

Targeting mitochondria by α-tocopheryl succinate kills neuroblastoma cells irrespective of MycN oncogene expression.

pubmed: neuroblastoma — Tue, 31 Jan 2012 11:23:30 GMT

Targeting mitochondria by α-tocopheryl succinate kills neuroblastoma cells irrespective of MycN oncogene expression. Cell Mol Life Sci. 2012 Jan 28; Authors: Kruspig B, Nilchian A, Bejarano I, Orrenius S, Zhivotovsky B, Gogvadze V Abstract Amplification of the MycN oncogene characterizes a subset of highly aggressive neuroblastomas, the most common extracranial solid tumor of childhood. However, the significance of MycN amplification for tumor cell survival is controversial, since down-regulation...(read more)

Gintonin, newly identified compounds from ginseng, is novel lysophosphatidic acids-protein complexes and activates G protein-coupled lysophosphatidic acid receptors with high affinity.

pubmed: neuroblastoma — Tue, 31 Jan 2012 11:23:29 GMT

Gintonin, newly identified compounds from ginseng, is novel lysophosphatidic acids-protein complexes and activates G protein-coupled lysophosphatidic acid receptors with high affinity. Mol Cells. 2012 Jan 27; Authors: Hwang SH, Shin TJ, Choi SH, Cho HJ, Lee BH, Pyo MK, Lee JH, Kang J, Kim HJ, Park CW, Shin HC, Nah SY Abstract Recently, we isolated a subset of glycolipoproteins from Panax ginseng, that we designated gintonin, and demonstrated that it induced [Ca(2+)](i) transients in cells via G-protein...(read more)

Anaplastic Lymphoma Kinase (ALK) regulates initiation of transcription of MYCN in neuroblastoma cells.

pubmed: neuroblastoma — Tue, 31 Jan 2012 11:23:29 GMT

Anaplastic Lymphoma Kinase (ALK) regulates initiation of transcription of MYCN in neuroblastoma cells. Oncogene. 2012 Jan 30; Authors: Schönherr C, Ruuth K, Kamaraj S, Wang CL, Yang HL, Combaret V, Djos A, Martinsson T, Christensen JG, Palmer RH, Hallberg B Abstract Neuroblastoma is a neural crest-derived embryonal tumour of the postganglionic sympathetic nervous system and a disease with several different chromosomal gains and losses, which include MYCN-amplified neuroblastoma on chromosome 2, deletions...(read more)

NEU4L sialidase overexpression promotes β-catenin signalling in neuroblastoma cells, enhancing stem-like malignant cell growth.

pubmed: neuroblastoma — Tue, 31 Jan 2012 11:23:19 GMT

NEU4L sialidase overexpression promotes β-catenin signalling in neuroblastoma cells, enhancing stem-like malignant cell growth. Int J Cancer. 2012 Jan 27; Authors: Tringali C, Cirillo F, Lamorte G, Papini N, Anastasia L, Lupo B, Silvestri I, Tettamanti G, Venerando B Abstract Neuroblastoma (NB) is a frequently lethal tumour that occurs in childhood and originates from embryonic neural crest cells. The malignant and aggressive phenotype of NB is strictly related to the de-regulation of pivotal pathways...(read more)

DNA demethylation increases sensitivity of neuroblastoma cells to chemotherapeutic drugs.

pubmed: neuroblastoma — Sat, 28 Jan 2012 11:21:32 GMT

DNA demethylation increases sensitivity of neuroblastoma cells to chemotherapeutic drugs. Biochem Pharmacol. 2012 Jan 18; Authors: Charlet J, Schnekenburger M, Brown KW, Diederich M Abstract Neuroblastoma is a common embryonal malignancy in which high-stage cases have a poor prognosis, often associated with resistance to chemotherapeutic drugs. DNA methylation alterations are frequent in neuroblastoma and can modulate sensitivity to chemotherapeutic drugs in other cancers, suggesting that manipulation...(read more)

Pen-2 overexpression induces Aβ-42 production, memory defect, motor activity enhancement and feeding behavior dysfunction in NSE/Pen-2 transgenic mice.

pubmed: neuroblastoma — Fri, 27 Jan 2012 11:16:47 GMT

Pen-2 overexpression induces Aβ-42 production, memory defect, motor activity enhancement and feeding behavior dysfunction in NSE/Pen-2 transgenic mice. Int J Mol Med. 2011 Dec;28(6):961-71 Authors: Nam SH, Seo SJ, Goo JS, Kim JE, Choi SI, Lee HR, Hwang IS, Jee SW, Lee SH, Bae CJ, Park JY, Kim HS, Shim SB, Hwang DY Abstract Pen-2 is a key regulator of the γ-secretase complex, which is involved in the production of the amyloid β (Aβ)-42 peptides, which ultimately lead to Alzheimer's disease (AD...(read more)