Assessing cytotoxicity of boron nitride nanotubes: Interference with the MTT assay.
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Assessing cytotoxicity of boron nitride nanotubes: Interference with the MTT assay.

Biochem Biophys Res Commun. 2010 Mar 9;

Authors: Ciofani G, Danti S, D'Alessandro D, Moscato S, Menciassi A

Thanks to a non-covalent wrapping with glycol-chitosan, highly biocompatible and highly concentrated dispersions of boron nitride nanotubes were obtained and tested on human neuroblastoma cells. A systematic investigation of the cytotoxicity of these nanovectors with several complementary qualitative and quantitative assays allowed to highlight a strong interference with the MTT metabolic assay, similar to a phenomenon already observed for carbon nanotubes, that would wrongly suggest toxicity of boron nitride nanotubes. These results confirm the high complexity of these new nanomaterials, and the needing of extensive investigations on their exciting potential applications in the biomedical field.

PMID: 20226164 [PubMed - as supplied by publisher]

Read the complete post at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20226164&dopt=Abstract

Posted 17 Mar 2010 3:57 AM by pubmed: neuroblastoma
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