Expression and Functional Role of Inhibitor-of-Apoptosis Protein Livin (BIRC7) in Neuroblastoma.
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Expression and Functional Role of Inhibitor-of-Apoptosis Protein Livin (BIRC7) in Neuroblastoma.

Biochem Biophys Res Commun. 2010 Aug 4;

Authors: Dasgupta A, Alvarado CS, Xu Z, Findley HW

We evaluated the expression of the inhibitor-of-apoptosis protein (IAP)livin (BIRC7)in 59 cases ofneuroblastoma (NBL) by quantitative RT-PCR.We also examined the role of livin in protecting tumor cells from chemotherapy drugs.Livin expression varied significantly amongtumors. High levels of expression were observed in 17 of 39 patients with advanced stages (stages 3 and 4) and 6 of 20 patients with localized stages (stages 1 and 2).Livin-transfected, MYCN-amplified NBL cells showed increased resistance to doxorubicin and etoposide. Conversely, livin knockdown with siRNA enhanced spontaneous and drug-induced apoptosis in NBL cells. Multivariate analysis of prognostic factors showed that high livin expression worsened prognosis for patients with MYCN-amplified tumors. Our data suggest thati. Livin is frequently expressed in NBL and protects tumor cells with amplified MYCN oncogene from genotoxic agents; ii. The antiapoptotic effect of livin in NBL is blocked by siRNA;iii. In the sample studied, high livin expression enhanced the adverse prognostic impact of MYCN amplification. These findings suggest that livin may contribute to drug resistance in NBL.

PMID: 20691667 [PubMed - as supplied by publisher]

Read the complete post at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20691667&dopt=Abstract

Posted 11 Aug 2010 8:23 AM by pubmed: neuroblastoma
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