Characterization of gene expression induced by RTN-1C in human neuroblastoma cells and in mouse brain.
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Characterization of gene expression induced by RTN-1C in human neuroblastoma cells and in mouse brain.

Neurobiol Dis. 2010 Aug 11;

Authors: Fazi B, Biancolella M, Mehdawy B, Corazzari M, Minella D, Blandini F, Moreno S, Nardacci R, Nisticò R, Sepe S, Novelli G, Piacentini M, Di Sano F

The endoplasmic reticulum (ER)-stress mediated pathway is involved in a wide range of human neurodegenerative disorders. Hence, molecules that regulate the ER stress response represent potential candidates as drug targets to tackle these diseases. In previous studies we demonstrated that upon acetylation the reticulon-1C (RTN-1C) variant of the reticulon family leads to inhibition of histone deacetylases (HDACs) enzymatic activity and endoplasmic reticulum stress-dependent apoptosis. Here, by microarray analysis of the whole human genome we found that RTN-1C is able to specifically regulate gene expression, modulating transcript clusters which have been implicated in the onset of neurodegenerative disorders. Interestingly, we show that some of the identified genes were also modulated in vivo in a brain-specific mouse model overxpressing RTN-1C. These data provide a basis for further investigation of RTN-1C as a potential molecular target for use in therapy and as a specific marker for neurological diseases.

PMID: 20708685 [PubMed - as supplied by publisher]

Read the complete post at http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?tmpl=NoSidebarfile&db=PubMed&cmd=Retrieve&list_uids=20708685&dopt=Abstract

Posted 17 Aug 2010 4:59 AM by pubmed: neuroblastoma
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