Neuroblastoma Research

Ceruloplasmin deficiency reduces levels of iron and BDNF in the cortex and striatum of young mice and increases their vulnerability to stroke.

2012-02-04T11:46:08Z

Ceruloplasmin deficiency reduces levels of iron and BDNF in the cortex and striatum of young mice and increases their vulnerability to stroke. PLoS One. 2011;6(9):e25077 Authors: Texel SJ, Zhang J, Camandola S, Unger EL, Taub DD, Koehler RC, Harris ZL, Mattson MP Abstract Ceruloplasmin (Cp) is an essential ferroxidase that plays important roles in cellular iron trafficking. Previous findings suggest that the proper regulation and subcellular localization of iron are very important in brain cell function...(read more)

Acitretin, an Enhancer of Alpha-Secretase Expression, Crosses the Blood-Brain Barrier and Is Not Eliminated by P-Glycoprotein.

2012-02-04T11:46:08Z

Acitretin, an Enhancer of Alpha-Secretase Expression, Crosses the Blood-Brain Barrier and Is Not Eliminated by P-Glycoprotein. Neurodegener Dis. 2012 Feb 1; Authors: Holthoewer D, Endres K, Schuck F, Hiemke C, Schmitt U, Fahrenholz F Abstract Background: ADAM10 (a disintegrin and metalloproteinase 10) has been demonstrated to act as the main physiological α-secretase. Enzymatic activity of the α-secretase on the one hand prevents the formation of toxic Aβ peptides and on the other hand promotes the...(read more)

The dopamine metabolite aminochrome inhibits mitochondrial complex I and modifies the expression of iron transporters DMT1 and FPN1.

2012-02-04T11:46:07Z

The dopamine metabolite aminochrome inhibits mitochondrial complex I and modifies the expression of iron transporters DMT1 and FPN1. Biometals. 2012 Feb 3; Authors: Aguirre P, Urrutia P, Tapia V, Villa M, Paris I, Segura-Aguilar J, Núñez MT Abstract Hallmarks of idiopathic and some forms of familial Parkinson's disease are mitochondrial dysfunction, iron accumulation and oxidative stress in dopaminergic neurons of the substantia nigra. There seems to be a causal link between these three conditions...(read more)

Novel GαS-Protein Signaling Associated with Membrane-Tethered Amyloid Precursor Protein Intracellular Domain.

2012-02-04T11:45:40Z

Novel GαS-Protein Signaling Associated with Membrane-Tethered Amyloid Precursor Protein Intracellular Domain. J Neurosci. 2012 Feb 1;32(5):1714-29 Authors: Deyts C, Vetrivel KS, Das S, Shepherd YM, Dupré DJ, Thinakaran G, Parent AT Abstract Numerous physiological functions, including a role as a cell surface receptor, have been ascribed to Alzheimer's disease-associated amyloid precursor protein (APP). However, detailed analysis of intracellular signaling mediated by APP in neurons has been lacking...(read more)

An extension of the single threshold design for monitoring efficacy and safety in phase II clinical trials.

2012-02-03T11:06:05Z

An extension of the single threshold design for monitoring efficacy and safety in phase II clinical trials. Stat Med. 2011 Jun 30;30(14):1648-64 Authors: Brutti P, Gubbiotti S, Sambucini V Abstract Tan and Machin (biStat. Med. 2002; 21:1991-2012) introduce a Bayesian two-stage design for phase II clinical trials where the binary endpoint of interest is treatment efficacy. In this paper we propose an extension of their design to incorporate safety considerations. At each stage we define the treatment...(read more)

Childhood cancer incidence and survival 2003-2005, Thailand: study from the thai pediatric oncology group.

2012-02-03T11:06:05Z

Childhood cancer incidence and survival 2003-2005, Thailand: study from the thai pediatric oncology group. Asian Pac J Cancer Prev. 2011;12(9):2215-20 Authors: Wiangnon S, Veerakul G, Nuchprayoon I, Seksarn P, Hongeng S, Krutvecho T, Sripaiboonkij N Abstract Background: Previous population-based incidences of childhood cancer in Thailand were achieved by extrapolating from data limited to a small number of cancer registries, not from the whole country. In addition, survival of childhood cancer patients...(read more)

Cellular consequences of the expression of Alzheimer's disease-causing presenilin 1 mutations in human neuroblastoma (SH-SY5Y) cells.

2012-02-03T11:06:05Z

Cellular consequences of the expression of Alzheimer's disease-causing presenilin 1 mutations in human neuroblastoma (SH-SY5Y) cells. Brain Res. 2012 Jan 12; Authors: Boyle JP, Hettiarachchi NT, Wilkinson JA, Pearson HA, Scragg JL, Lendon C, Al-Owais MM, Kim CB, Myers DM, Warburton P, Peers C Abstract Mutations in the presenilin 1 (PS1) gene lead to early-onset Alzheimer's disease with the S170F mutation causing the earliest reported age of onset. Expression of this, and other PS1 mutations...(read more)

Protection of prenylated flavonoids from mori cortex radicis (Moraceae) against nitric oxide-induced cell death in neuroblastoma SH-SY5Y cells.

2012-02-03T11:06:04Z

Protection of prenylated flavonoids from mori cortex radicis (Moraceae) against nitric oxide-induced cell death in neuroblastoma SH-SY5Y cells. Arch Pharm Res. 2012 Jan;35(1):163-70 Authors: Lee HJ, Lyu da H, Koo U, Nam KW, Hong SS, Kim KO, Kim KH, Lee D, Mar W Abstract Seven prenylated flavanoids, licoflavone C (1), cyclomulberrin (2), neocyclomorusin (3), sanggenon I (4), morusin (5), kuwanon U (6) and kuwanon E (7), and three 2-arylbenzofurans, moracin P (8), moracin O (9), and mulberrofuran Q...(read more)

Arylpiperazine Dopamineric Ligands Protect Neuroblastoma Cells from Nitric Oxide (NO)-Induced Mitochondrial Damage and Apoptosis.

2012-02-03T11:06:04Z

Arylpiperazine Dopamineric Ligands Protect Neuroblastoma Cells from Nitric Oxide (NO)-Induced Mitochondrial Damage and Apoptosis. ChemMedChem. 2012 Feb 1; Authors: Tovilovic G, Zogovic N, Harhaji-Trajkovic L, Misirkic-Marjanovic M, Janjetovic K, Vucicevic L, Kostic-Rajacic S, Schrattenholz A, Isakovic A, Soskic V, Trajkovic V Abstract The protective ability of novel arylpiperazine-based dopaminergic ligands against nitric oxide (NO)-mediated neurotoxicity is investigated. The most potent neuroprotective...(read more)

Tumor-initiating cells in childhood neuroblastoma--letter.

2012-02-03T11:06:04Z

Tumor-initiating cells in childhood neuroblastoma--letter. Cancer Res. 2012 Feb 1;72(3):821-2 Authors: Mohlin S, Pietras A, Wigerup C, Ora I, Andäng M, Nilsson K, Olofsson T, Gisselsson D, Påhlman S PMID: 22298597 [PubMed - in process]...(read more)

Tumor-initiating cells in childhood neuroblastoma--response.

2012-02-03T11:06:04Z

Tumor-initiating cells in childhood neuroblastoma--response. Cancer Res. 2012 Feb 1;72(3):823-4 Authors: Hansford LM, Kaplan DR PMID: 22298598 [PubMed - in process]...(read more)

Activated β-catenin Forces N2A Cell-derived Neurons Back to Tumor-like Neuroblasts and Positively Correlates with a Risk for Human Neuroblastoma.

2012-02-03T11:05:52Z

Activated β-catenin Forces N2A Cell-derived Neurons Back to Tumor-like Neuroblasts and Positively Correlates with a Risk for Human Neuroblastoma. Int J Biol Sci. 2012;8(2):289-97 Authors: Zhi F, Gong G, Xu Y, Zhu Y, Hu D, Yang Y, Hu Y Abstract Neuroblastoma is an embryonic malignancy arising from neuroblasts. The mechanisms that regulate the origination of neuroblastoma are still not very clear. In this study, we revealed that 6-bromoindirubin 3'-oxime (BIO), a specific GSK-3β inhibitor, promoted...(read more)

Influence of a 50 Hz magnetic field and of all-trans‑retinol on the proliferation of human cancer cell lines.

2012-02-02T12:01:00Z

Influence of a 50 Hz magnetic field and of all-trans‑retinol on the proliferation of human cancer cell lines. Int J Oncol. 2012 Jan 27; Authors: Trillo MA, Martínez MA, Cid MA, Leal J, Ubeda A Abstract In vitro exposure to power frequency magnetic fields (MF) has been reported to influence cell proliferation and differentiation. However, the nature of the response of different human cancer cell types to these fields has not been sufficiently characterized. The present work investigates the response...(read more)

Shifting from Population-wide to Personalized Cancer Prognosis with Microarrays.

2012-02-02T12:00:59Z

Shifting from Population-wide to Personalized Cancer Prognosis with Microarrays. PLoS One. 2012;7(1):e29534 Authors: Shao L, Fan X, Cheng N, Wu L, Xiong H, Fang H, Ding D, Shi L, Cheng Y, Tong W Abstract The era of personalized medicine for cancer therapeutics has taken an important step forward in making accurate prognoses for individual patients with the adoption of high-throughput microarray technology. However, microarray technology in cancer diagnosis or prognosis has been primarily used for...(read more)

Calpastatin upregulation in Mycoplasma hyorhinis-infected cells is promoted by the mycoplasma lipoproteins via the NF-κB pathway.

2012-02-01T11:41:59Z

Calpastatin upregulation in Mycoplasma hyorhinis-infected cells is promoted by the mycoplasma lipoproteins via the NF-κB pathway. Cell Microbiol. 2012 Jan 31; Authors: Elkind E, Vaisid T, Kornspan JD, Barnoy S, Rottem S, Kosower NS Abstract Mycoplasma hyorhinis frequently contaminates cultured cells, with effects on synthetic and metabolic pathways. We demonstrated for the first time that contamination of cells by a strain of M. hyorhinis (NDMh) results in increased levels of calpastatin (the endogenous...(read more)