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Anaplastic Lymphoma Kinase (ALK) regulates initiation of transcription of MYCN in neuroblastoma cells. Oncogene. 2012 Jan 30; Authors: Schönherr C, Ruuth K, Kamaraj S, Wang CL, Yang HL, Combaret V, Djos A, Martinsson T, Christensen JG, Palmer RH, Hallberg B Abstract Neuroblastoma is a neural crest-derived...
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Intersectin 1 is required for neuroblastoma tumorigenesis. Oncogene. 2012 Jan 23; Authors: Russo A, O'Bryan JP Abstract Intersectin 1 (ITSN1) is a scaffold protein that regulates diverse cellular pathways, including endocytosis and several signal transduction pathways, including phosphatidylinositol...
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Antibody targeting of anaplastic lymphoma kinase induces cytotoxicity of human neuroblastoma. Oncogene. 2012 Jan 23; Authors: Carpenter EL, Haglund EA, Mace EM, Deng D, Martinez D, Wood AC, Chow AK, Weiser DA, Belcastro LT, Winter C, Bresler SC, Asgharzadeh S, Seeger RC, Zhao H, Guo R, Christensen JG...
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Aberrant activation of ALK kinase by a novel truncated form ALK protein in neuroblastoma. Oncogene. 2012 Jan 16; Authors: Okubo J, Takita J, Chen Y, Oki K, Nishimura R, Kato M, Sanada M, Hiwatari M, Hayashi Y, Igarashi T, Ogawa S Abstract Anaplastic lymphoma kinase (ALK) was originally identified from...
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MiR-27b targets PPARγ to inhibit growth, tumor progression and the inflammatory response in neuroblastoma cells. Oncogene. 2011 Nov 28; Authors: Lee JJ, Drakaki A, Iliopoulos D, Struhl K Abstract The peroxisome proliferators-activated receptor (PPAR)γ pathway is involved in cancer, but it appears to...
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Cyclin E1 is a common target of BMI1 and MYCN and a prognostic marker for neuroblastoma progression. Oncogene. 2011 Nov 28; Authors: Mao L, Ding J, Perdue A, Yang L, Zha Y, Ren M, Huang S, Cui H, Ding HF Abstract The Polycomb transcription repressor BMI1 is highly expressed in human neuroblastomas and...
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Oncogenic activation of FOXR1 by 11q23 intrachromosomal deletion-fusions in neuroblastoma. Oncogene. 2011 Aug 22; Authors: Santo EE, Ebus ME, Koster J, Schulte JH, Lakeman A, van Sluis P, Vermeulen J, Gisselsson D, Ora I, Lindner S, Buckley PG, Stallings RL, Vandesompele J, Eggert A, Caron HN, Versteeg...
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MDM2 regulates MYCN mRNA stabilization and translation in human neuroblastoma cells. Oncogene. 2011 Aug 8; Authors: Gu L, Zhang H, He J, Li J, Huang M, Zhou M The MYCN gene has a critical role in determining the clinical behavior of neuroblastoma. Although it is known that genomic amplification occurs...
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MYCN sensitizes neuroblastoma to the MDM2-p53 antagonists Nutlin-3 and MI-63. Oncogene. 2011 Jul 4; Authors: Gamble LD, Kees UR, Tweddle DA, Lunec J MYCN amplification is a major biomarker of poor prognosis, occurring in 25-30% of neuroblastomas. MYCN has contradictory roles in promoting cell growth...
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Related Articles PI3K inhibitors prime neuroblastoma cells for chemotherapy by shifting the balance towards pro-apoptotic Bcl-2 proteins and enhanced mitochondrial apoptosis. Oncogene. 2010 Sep 20; Authors: Bender A, Opel D, Naumann I, Kappler R, Friedman L, von Schweinitz D, Debatin KM, Fulda S We recently...
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Related Articles CD133 suppresses neuroblastoma cell differentiation via signal pathway modification. Oncogene. 2010 Sep 6; Authors: Takenobu H, Shimozato O, Nakamura T, Ochiai H, Yamaguchi Y, Ohira M, Nakagawara A, Kamijo T CD133 (prominin-1) is a transmembrane glycoprotein expressed on the surface...
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Related Articles TRIM16 acts as a tumour suppressor by inhibitory effects on cytoplasmic vimentin and nuclear E2F1 in neuroblastoma cells. Oncogene. 2010 Aug 23; Authors: Marshall GM, Bell JL, Koach J, Tan O, Kim P, Malyukova A, Thomas W, Sekyere EO, Liu T, Cunningham AM, Tobias V, Norris MD, Haber M...
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Related Articles Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects. Oncogene. 2010 Aug 9; Authors: Marshall GM, Gherardi S, Xu N, Neiron Z, Trahair T, Scarlett CJ, Chang DK, Liu PY, Jankowski K, Iraci N, Haber M, Norris MD, Keating J, Sekyere E, Jonquieres G...
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Neuropeptide Y and its Y2 receptor: potential targets in neuroblastoma therapy. Oncogene. 2010 Aug 2; Authors: Lu C, Everhart L, Tilan J, Kuo L, Sun CC, Munivenkatappa RB, Jönsson-Rylander AC, Sun J, Kuan-Celarier A, Li L, Abe K, Zukowska Z, Toretsky JA, Kitlinska J Neuroblastomas are pediatric tumors...
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Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma. Oncogene. 2010 Jun 21; Authors: Shang X, Vasudevan SA, Yu Y, Ge N, Ludwig AD, Wesson CL, Wang K, Burlingame SM, Zhao YJ, Rao PH, Lu X, Russell HV, Okcu MF, Hicks MJ, Shohet JM...