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Brand name: cozaar
Generic name: Losartan
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, those treated with diuretics), symptomatic hypotension may occur after initiation of therapy with Cozaar. However, the LIFE study provides no evidence that the benefits of Cozaar on reducing the risk of cardiovascular events in hypertensive patients with left ventricular hypertrophy apply to Black patients. However, the LIFE study does not provide evidence that the benefits of Cozaar on reducing the risk of cardiovascular events in hypertensive patients with left ventricular hypertrophy apply to Black patients. 5�mg) was added first and, if needed, the dose of Cozaar or atenolol was then increased to 100�mg once daily. Cozaar 25 mg, Cozaar 50 mg, and Cozaar 100 mg may also contain carnauba wax. Of the patients still taking study medication, the mean doses of Cozaar and atenolol were both about 80�mg/day, and 15% were taking atenolol or losartan as monotherapy, while 77% were also receiving hydrochlorothiazide (at a mean dose of 20�mg/day in each group). At the end of study or at the last visit before a primary endpoint, 77% of the group treated with Cozaar and 73% of the group treated with atenolol were still taking study medication. In this population, Cozaar reduces the rate of progression of nephropathy as measured by the occurrence of doubling of serum creatinine or end stage renal disease (need for dialysis or renal transplantation) (see CLINICAL PHARMACOLOGY, Pharmacodynamics and Clinical Effects). Compared with placebo, Cozaar significantly reduced proteinuria by an average of 34%, an effect that was evident within 3 months of starting therapy, and significantly reduced the rate of decline in glomerular filtration rate during the study by 13%, as measured by the reciprocal of the serum creatinine concentration. Similar effects have been reported with Cozaar; in some patients, these effects were reversible upon discontinuation of therapy.

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